Transitioning from a fossil- to renewable-based global economy requires a major shift in the way we think about every aspect of life. Central to this transformation is the careful design of chemicals that prioritize both performance and sustainability. Emphasizing a product’s value proposition will be linked to its functional benefits and sustainability metrics rather than sheer chemical volume. There are already many examples of green chemistry developments, demonstrating that change is on the way. This presentation showcases diverse industry examples to underscore the growing influence of green chemistry across sectors, signaling a path towards a sustainable future. Specifically, we highlight fermentation chemicals as a strategic avenue in green chemistry. These chemicals, derived from biomass via microbial fermentation processes involving organisms like bacteria, yeasts, fungi, and microalgae, offer sustainable building blocks for innovative products spanning various applications. Investing in these technologies is crucial for maintaining a competitive edge amidst evolving market demands.